Digital Mental Health Interventions: A Comprehensive Systematic Review


  • Sarah Alnaher 7450 Summit Cir, Davison, MI 48423
  • Mohammed Alnaher
  • Mouyad Alramahi
  • Abdul Karim Arida



With the emergence of smartphone applications, chatbots, and AI-powered technologies in recent years, digital mental health interventions have grown in popularity. The purpose of this systematic review was to assess the efficacy and morality of these technologies in delivering care and support for mental health. A thorough review of the relevant research revealed that digital treatments in mental health have the potential for increasing the availability and cost of mental health care. However, difficulties with data privacy, ethical issues, and the requirement for more study were also noted. This study gives recommendations for future research and practice as well as insightful information about the state of digital mental health interventions now.

Keywords: Digital health, AI-powered technologies, mental health treatment, costs, ethical issues, and digital interventions


L R de F. Mental Disorders and Psychosocial Functioning. Mental Health & Human Resilience International Journal. 2018; 2(1).

Lattie EG, Adkins EC, Winquist N, Stiles-Shields C, Wafford QE, Graham AK. Digital Mental Health Interventions for Depression, Anxiety, and Enhancement of Psychological Well-Being among College Students: Systematic Review. Journal of Medical Internet Research [Internet]. 2019 Jul 22; 21(7):e12869. Available from:

Borghouts J, Eikey E, Mark G, De Leon C, Schueller SM, Schneider M, et al. Barriers to and Facilitators of User Engagement With Digital Mental Health Interventions: Systematic Review. Journal of Medical Internet Research. 2021 Mar 24; 23(3):e24387.

Garrido S, Millington C, Cheers D, Boydell K, Schubert E, Meade T, et al. What Works and What Doesn’t Work? A Systematic Review of Digital Mental Health Interventions for Depression and Anxiety in Young People. Frontiers in Psychiatry. 2019 Nov 13; 10(759).

Strauss P, Morgan H, Wright Toussaint D, Lin A, Winter S, Perry Y. Trans and gender diverse young people’s attitudes towards game-based digital mental health interventions: A qualitative investigation. Internet Interventions [Internet]. 2019 Dec 1; 18:100280. Available from:

Graham AK, Lattie EG, Powell BJ, Lyon AR, Smith JD, Schueller SM, et al. Implementation strategies for digital mental health interventions in health care settings. American Psychologist. 2020 Nov; 75(8):1080–92.

Boucher EM, Harake NR, Ward HE, Stoeckl SE, Vargas J, Minkel J, et al. Artificially intelligent chatbots in digital mental health interventions: a review. Expert Review of Medical Devices. 2021 Dec 3; 18(sup1):37–49.

Kretzschmar K, Tyroll H, Pavarini G, Manzini A, Singh I. Can Your Phone Be Your Therapist? Young People’s Ethical Perspectives on the Use of Fully Automated Conversational Agents (Chatbots) in Mental Health Support. Biomedical Informatics Insights [Internet]. 2019 Jan [cited 2020 Jul 9]; 11:117822261982908. Available from:

Bendig E, Erb B, Schulze-Thuesing L, Baumeister H. The Next Generation: Chatbots in Clinical Psychology and Psychotherapy to Foster Mental Health – A Scoping Review. Verhaltenstherapie [Internet]. 2019 Aug 20 [cited 2020 Jun 12]; 1–13. Available from:

Dash S, Shakyawar SK, Sharma M, Kaushik S. Big data in healthcare: management, analysis and future prospects. Journal of Big Data. 2019 Jun 19; 6(1):1–25.

Zhou X, Snoswell CL, Harding LE, Bambling M, Edirippulige S, Bai X, et al. The role of telehealth in reducing the mental health burden from COVID-19. Telemedicine and e-Health [Internet]. 2020 Mar 23; 26(4):377–9. Available from:

Bettis AH, Burke TA, Nesi J, Liu RT. Digital Technologies for Emotion-Regulation Assessment and Intervention: A Conceptual Review. Clinical Psychological Science. 2021 Jun 3; 10(1):216770262110119.

Berry N, Lobban F, Bucci S. A qualitative exploration of service user views about using digital health interventions for self-management in severe mental health problems. BMC Psychiatry. 2019 Jan 21; 19(1).

Perski O, Blandford A, West R, Michie S. Conceptualising engagement with digital behaviour change interventions: a systematic review using principles from critical interpretive synthesis. Translational Behavioral Medicine. 2016 Dec 13; 7(2):254–67.

D’Alfonso S, Lederman R, Bucci S, Berry K. The Digital Therapeutic Alliance and Human-Computer Interaction. JMIR Mental Health. 2020 Dec 29; 7(12):e21895.

Torous J, Wisniewski H, Bird B, Carpenter E, David G, Elejalde E, et al. Creating a Digital Health Smartphone App and Digital Phenotyping Platform for Mental Health and Diverse Healthcare Needs: an Interdisciplinary and Collaborative Approach. Journal of Technology in Behavioral Science. 2019 Apr 27; 4(2):73–85.

Alvarez-Jimenez M, Rice S, D’Alfonso S, Leicester S, Bendall S, Pryor I, et al. A Novel Multimodal Digital Service (Moderated Online Social Therapy+) for Help-Seeking Young People Experiencing Mental Ill-Health: Pilot Evaluation Within a National Youth E-Mental Health Service. Journal of Medical Internet Research. 2020 Aug 13; 22(8):e17155.

Hornstein S, Forman-Hoffman V, Nazander A, Ranta K, Hilbert K. Predicting therapy outcome in a digital mental health intervention for depression and anxiety: A machine learning approach. DIGITAL HEALTH. 2021 Jan; 7:205520762110606.

Lattie EG, Adkins EC, Winquist N, Stiles-Shields C, Wafford QE, Graham AK. Digital Mental Health Interventions for Depression, Anxiety, and Enhancement of Psychological Well-Being among College Students: Systematic Review. Journal of Medical Internet Research [Internet]. 2019 Jul 22; 21(7):e12869. Available from:

Scholten H, Granic I. Use of the Principles of Design Thinking to Address Limitations of Digital Mental Health Interventions for Youth: Viewpoint. Journal of Medical Internet Research. 2019 Jan 14; 21(1):e11528.

Chandrashekar P. Do mental health mobile apps work: evidence and recommendations for designing high-efficacy mental health mobile apps. mHealth [Internet]. 2018 Mar 23; 4(6):6–6. Available from:

Baillie AJ, Rapee RM. Predicting who benefits from psychoeducation and self-help for panic attacks. Behaviour Research and Therapy. 2004 May; 42(5):513–27.

Rathnayaka P, Mills N, Burnett D, De Silva D, Alahakoon D, Gray R. A Mental Health Chatbot with Cognitive Skills for Personalised Behavioural Activation and Remote Health Monitoring. Sensors. 2022 May 11; 22(10):3653.

Andersson G, Titov N. Advantages and limitations of Internet-based interventions for common mental disorders. World Psychiatry [Internet]. 2014 Feb; 13(1):4–11. Available from:

Chow J, Xu L. Chatbot for Healthcare and Oncology Applications Using Artificial Intelligence and Machine Learning (Preprint). JMIR Cancer. 2021 Feb 9; 7(4).




How to Cite

Alnaher, S., M. Alnaher, M. Alramahi, and A. K. Arida. “Digital Mental Health Interventions: A Comprehensive Systematic Review”. Journal of Sociology, Psychology & Religious Studies, vol. 5, no. 2, Dec. 2023, pp. 108-22, doi:10.53819/81018102t4236.